population-based simulator simcyp version 13.1 Search Results


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Population Based Adme Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Population Based Pharmacokinetic Simulator Version 14, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Population Based Adme Simulator Version 21, Release 1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population-based simulator simcyp v15.1  (Simcyp)
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Population Based Simulator Simcyp V15.1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population-based simulator  (Simcyp)
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Simcyp population-based simulator
Population Based Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population-based simulator v13r1  (Simcyp)
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Simcyp population-based simulator v13r1
Population Based Simulator V13r1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population-based simulation system using pbpk model  (Simcyp)
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Simcyp population-based simulation system using pbpk model
Population Based Simulation System Using Pbpk Model, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population- based simulator version 17 release 1  (Simcyp)
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Simcyp population- based simulator version 17 release 1
Population Based Simulator Version 17 Release 1, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pbpk modeling in the simcyp population-based simulator  (Simcyp)
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Pbpk Modeling In The Simcyp Population Based Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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simcyp population-based simulator  (Simcyp)
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Simcyp simcyp population-based simulator
Simcyp Population Based Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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population-based pbpk simulator software  (Simcyp)
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Simcyp population-based pbpk simulator software
Workflow of the development and application of the <t>PBPK</t> kidney model for digoxin.
Population Based Pbpk Simulator Software, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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simcyp simulator population-based pbpk software  (Certara L.P)
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Certara L.P simcyp simulator population-based pbpk software
Workflow of the development and application of the <t>PBPK</t> kidney model for digoxin.
Simcyp Simulator Population Based Pbpk Software, supplied by Certara L.P, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Workflow of the development and application of the PBPK kidney model for digoxin.

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

doi: 10.1124/jpet.116.237438

Figure Lengend Snippet: Workflow of the development and application of the PBPK kidney model for digoxin.

Article Snippet: All simulations presented herein were performed using the SimCYP population-based PBPK simulator software, version 14, release 1 (SimCYP, Sheffield, UK) ( ; ).

Techniques:

Mean simulated digoxin plasma concentration time profiles (intravenous administration of 1 mg digoxin) for intermediate PBPK models used during development of the mechanistic kidney model. CL R defined by a single input value (136.1 ml/ min) based on the literature analysis (orange line) and CL R simulated using the mechanistic kidney model, accounting for only glomerular filtration (purple line), glomerular filtration and reabsorption (turquoise line), or glomerular filtration, reabsorption, and active secretion (blue line).

Journal: The Journal of Pharmacology and Experimental Therapeutics

Article Title: Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

doi: 10.1124/jpet.116.237438

Figure Lengend Snippet: Mean simulated digoxin plasma concentration time profiles (intravenous administration of 1 mg digoxin) for intermediate PBPK models used during development of the mechanistic kidney model. CL R defined by a single input value (136.1 ml/ min) based on the literature analysis (orange line) and CL R simulated using the mechanistic kidney model, accounting for only glomerular filtration (purple line), glomerular filtration and reabsorption (turquoise line), or glomerular filtration, reabsorption, and active secretion (blue line).

Article Snippet: All simulations presented herein were performed using the SimCYP population-based PBPK simulator software, version 14, release 1 (SimCYP, Sheffield, UK) ( ; ).

Techniques: Concentration Assay, Filtration